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Change in Stability Constant Calculator

Formula Used:

\[ km = 10^{\log_{10}(KMAB)-(\log_{10}(kMA)+\log_{10}(kMB))} \]

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1. What is Change in Stability Constant?

Definition: The difference between the stability constant of ternary complex and summation of all binary complexes.

Purpose: This calculation helps in understanding the relative stability of ternary complexes compared to their binary counterparts.

2. How Does the Calculator Work?

The calculator uses the formula:

\[ km = 10^{\log_{10}(KMAB)-(\log_{10}(kMA)+\log_{10}(kMB))} \]

Where:

Explanation: The formula calculates the logarithmic difference between the ternary complex stability and the sum of binary complex stabilities.

3. Importance of Stability Constant Calculation

Details: Understanding stability constants helps predict complex formation, reaction pathways, and relative stabilities of different complexes.

4. Using the Calculator

Tips: Enter the stability constants for the ternary complex (KMAB) and both binary complexes (kMA and kMB). All values must be > 0.

5. Frequently Asked Questions (FAQ)

Q1: What does a high km value indicate?
A: A high km value suggests the ternary complex is significantly more stable than the combination of the binary complexes.

Q2: What units are used for stability constants?
A: Stability constants are typically dimensionless as they represent equilibrium constants.

Q3: How precise should my input values be?
A: Use as many significant figures as available, as small differences can significantly impact the result.

Q4: Can this calculator be used for other types of complexes?
A: Yes, the same principle applies to any ternary complex formation from binary complexes.

Q5: What does a km value of 1 mean?
A: A value of 1 indicates no change in stability between the ternary complex and the combination of binary complexes.

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