1. What is the Amount of Drug Administered Calculation?

The amount of drug administered calculation determines the dose of a drug based on its volume of distribution and target plasma concentration. This is fundamental in pharmacokinetics for determining appropriate drug dosing regimens.

2. How Does the Calculator Work?

The calculator uses the formula:

Where:

• \( D \) — Dose (moles)
• \( V_{dis} \) — Volume of distribution (m³)
• \( C_{ss} \) — Steady-state concentration of drug (mol/m³)

Explanation: The formula calculates the amount of drug needed to achieve a specific plasma concentration based on the drug's distribution characteristics in the body.

3. Importance of Dose Calculation

Details: Accurate dose calculation is crucial for achieving therapeutic drug levels while avoiding toxicity. It's essential for designing effective and safe medication regimens.

4. Using the Calculator

Tips: Enter volume of distribution in m³ and target drug concentration in mol/m³. Both values must be positive numbers.

5. Frequently Asked Questions (FAQ)

Q1: What is volume of distribution?
A: Volume of distribution is a theoretical volume that relates the amount of drug in the body to the concentration of drug measured in the blood.

Q2: Why is steady-state concentration important?
A: Steady-state concentration is the plasma concentration achieved when the rate of drug administration equals the rate of drug elimination.

Q3: How does volume of distribution affect dosing?
A: Drugs with larger volumes of distribution require higher doses to achieve the same plasma concentration compared to drugs with smaller volumes of distribution.

Q4: Are there limitations to this calculation?
A: This calculation assumes linear pharmacokinetics and may not account for factors like protein binding, tissue binding, or non-linear elimination.

Q5: When should this calculation be used?
A: This calculation is particularly useful for loading doses and for drugs that follow one-compartment model pharmacokinetics.