Home
Back
Formula Used:
| From: | To: |
The formula Dose = Volume of Plasma Cleared × Area Under Curve (D = CL × AUC) is used to calculate the amount of drug administered based on pharmacokinetic parameters. This equation is fundamental in determining the appropriate drug dosage for therapeutic effectiveness.
The calculator uses the formula:
Where:
Explanation: The formula calculates the total amount of drug administered by multiplying the plasma clearance rate by the area under the plasma concentration-time curve.
Details: Accurate dose calculation is essential for ensuring therapeutic drug levels, avoiding toxicity, and achieving desired pharmacological effects. This calculation is particularly important in pharmacokinetic studies and clinical drug dosing.
Tips: Enter the volume of plasma cleared in m³/s and the area under curve in mol·s/m³. Both values must be positive numbers for accurate calculation.
Q1: What is Volume of Plasma Cleared (CL)?
A: Volume of Plasma Cleared represents the volume of plasma from which the drug is completely removed per unit time. It's a measure of the body's efficiency in eliminating the drug.
Q2: What does Area Under Curve (AUC) represent?
A: AUC represents the total drug exposure over time. It's calculated as the integral of the drug concentration-time curve and reflects the body's overall exposure to the drug.
Q3: Why is this calculation important in pharmacology?
A: This calculation helps determine the appropriate drug dosage needed to achieve and maintain therapeutic drug levels in the body, ensuring effective treatment while minimizing side effects.
Q4: What units should be used for accurate results?
A: For consistent results, use m³/s for plasma clearance and mol·s/m³ for area under curve. The result will be in moles.
Q5: Can this formula be used for all drugs?
A: While the basic principle applies to most drugs, specific pharmacokinetic characteristics of individual drugs (such as metabolism pathways and elimination rates) should be considered for precise dosing.