Area Under Curve For Drug Administered Orally Calculator

Formula Used:

\[ AUC_{po} = \frac{f \times AUC_{iv} \times D_{po}}{D_{iv}} \]

Bioavailability of Drug (f):

Area under Curve Intravenous (AUC_iv):

Mole Second per Cubic Meter

Dose Non-Intravenous (D_po):

Mole

Dose Intravenous (D_iv):

Mole

Area under Curve Non-Intravenous (AUC_po):

Mole Second per Cubic Meter

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1. What is the Area under Curve Calculation?

The Area under Curve (AUC) calculation determines the integral of the concentration-time curve for a drug administered orally, based on intravenous reference data and bioavailability. It provides a measure of total drug exposure in the body.

2. How Does the Calculator Work?

The calculator uses the formula:

\[ AUC_{po} = \frac{f \times AUC_{iv} \times D_{po}}{D_{iv}} \]

Where:

\( AUC_{po} \) — Area under Curve Non-Intravenous (Mole Second per Cubic Meter)
\( f \) — Bioavailability of Drug (unitless fraction)
\( AUC_{iv} \) — Area under Curve Intravenous (Mole Second per Cubic Meter)
\( D_{po} \) — Dose Non-Intravenous (Mole)
\( D_{iv} \) — Dose Intravenous (Mole)

Explanation: This formula calculates oral drug exposure by scaling the intravenous AUC by the bioavailability factor and dose ratio.

3. Importance of AUC Calculation

Details: Accurate AUC estimation is crucial for determining drug exposure, bioavailability studies, and establishing dose-response relationships in pharmacokinetics.

4. Using the Calculator

Tips: Enter all values as positive numbers. Bioavailability (f) should be between 0 and 1, representing the fraction of drug that reaches systemic circulation.

5. Frequently Asked Questions (FAQ)

Q1: What does bioavailability (f) represent?
A: Bioavailability represents the fraction of an administered dose that reaches the systemic circulation unchanged.

Q2: Why use intravenous data as reference?
A: Intravenous administration provides 100% bioavailability, making it the ideal reference for comparing other routes of administration.

Q3: What are typical bioavailability values?
A: Bioavailability ranges from 0 to 1, with values varying significantly between drugs and formulations.

Q4: When is this calculation most useful?
A: This calculation is particularly valuable in pharmacokinetic studies and drug development when comparing different formulations or routes of administration.

Q5: Are there limitations to this approach?
A: This method assumes linear pharmacokinetics and may not account for factors like first-pass metabolism or non-linear clearance.