1. What is Bioavailability?

Bioavailability is the systemically available fraction of a drug. It represents the proportion of an administered dose that reaches the systemic circulation and is available to produce its pharmacological effects.

2. How Does the Calculator Work?

The calculator uses the Bioavailability formula:

Where:

• \( B \) — Bioavailability (unitless)
• \( De \) — Effective Dose (kg)
• \( Da \) — Administered Dose (kg)

Explanation: The formula calculates the fraction of the administered dose that produces the desired pharmacological response.

3. Importance of Bioavailability Calculation

Details: Bioavailability is crucial for determining appropriate drug dosing, comparing different drug formulations, and assessing the efficiency of drug delivery systems.

4. Using the Calculator

Tips: Enter both effective dose and administered dose in kilograms. Both values must be valid (greater than 0). The result represents the bioavailability fraction.

5. Frequently Asked Questions (FAQ)

Q1: What is considered good bioavailability?
A: Bioavailability values range from 0 to 1 (or 0-100%). Higher values indicate better drug absorption and availability.

Q2: Why is bioavailability important in drug development?
A: It helps pharmaceutical companies optimize drug formulations and determine appropriate dosing regimens for maximum therapeutic effect.

Q3: What factors affect bioavailability?
A: Factors include drug formulation, route of administration, metabolism, first-pass effect, and individual patient factors.

Q4: How does route of administration affect bioavailability?
A: Intravenous administration typically has 100% bioavailability, while oral administration often has lower bioavailability due to first-pass metabolism.

Q5: Can bioavailability exceed 1?
A: No, bioavailability is a fraction and should theoretically range between 0 and 1, though measurement variations may occasionally produce values slightly above 1.