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Bioavailability Formula:
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The Bioavailability Of Drug Dose describes the fraction or percentage of an administered drug that reaches the systemic circulation in an unchanged and active form. It is a crucial pharmacokinetic parameter that determines the effectiveness of drug delivery.
The calculator uses the Bioavailability formula:
Where:
Explanation: The formula calculates the percentage of the administered drug dose that reaches systemic circulation based on volume of distribution, target plasma concentration, and loading dose.
Details: Accurate bioavailability calculation is essential for determining appropriate drug dosing, optimizing therapeutic efficacy, and minimizing side effects. It helps in designing effective drug delivery systems and formulations.
Tips: Enter volume of distribution in m³, target plasma concentration in kg/m³, and loading dose in kg. All values must be positive numbers greater than zero.
Q1: What factors affect drug bioavailability?
A: Factors include drug formulation, route of administration, metabolism, first-pass effect, solubility, and patient-specific factors like age and health status.
Q2: What is considered good bioavailability?
A: Bioavailability above 80% is generally considered excellent, while values below 50% may indicate poor absorption or extensive first-pass metabolism.
Q3: How does route of administration affect bioavailability?
A: Intravenous administration provides 100% bioavailability, while oral administration typically has lower bioavailability due to first-pass metabolism and incomplete absorption.
Q4: Why is bioavailability important in drug development?
A: It helps determine appropriate dosing regimens, compare different formulations, and ensure consistent therapeutic effects across patient populations.
Q5: Can bioavailability be improved?
A: Yes, through various formulation strategies such as prodrug design, nanoparticle delivery systems, and absorption enhancers.