Relative Bioavailability Of Drug Calculator

Relative Bioavailability Formula:

\[ F_{rel} = \frac{AUC_{dosageA}}{AUC_{dosageB}} \times \frac{D_B}{D_A} \]

Area Under Curve Dosage A:

Mole Second per Cubic Meter

Area Under Curve Dosage B:

Mole Second per Cubic Meter

Dose Type B:

Mole

Dose Type A:

Mole

Relative Bioavailability (Frel):

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1. What is Relative Bioavailability?

Relative Bioavailability compares the bioavailability between two different dosage forms of the same drug. It helps determine how much of a drug reaches the systemic circulation compared to a reference formulation.

2. How Does the Calculator Work?

The calculator uses the Relative Bioavailability formula:

\[ F_{rel} = \frac{AUC_{dosageA}}{AUC_{dosageB}} \times \frac{D_B}{D_A} \]

Where:

\( AUC_{dosageA} \) — Area under curve for dosage form A (Mole Second per Cubic Meter)
\( AUC_{dosageB} \) — Area under curve for dosage form B (Mole Second per Cubic Meter)
\( D_B \) — Dose of type B formulation (Mole)
\( D_A \) — Dose of type A formulation (Mole)

Explanation: The formula compares the systemic exposure of two different dosage forms, normalized by their respective doses.

3. Importance of Relative Bioavailability Calculation

Details: Calculating relative bioavailability is crucial for pharmaceutical development, formulation optimization, and determining bioequivalence between different drug products.

4. Using the Calculator

Tips: Enter all values in the specified units. Ensure all inputs are positive numbers greater than zero for accurate calculation.

5. Frequently Asked Questions (FAQ)

Q1: What does a relative bioavailability of 1 mean?
A: A value of 1 indicates that both formulations have equal bioavailability - they deliver the same amount of drug to the systemic circulation.

Q2: What is considered bioequivalent?
A: Typically, formulations are considered bioequivalent if the 90% confidence interval of the relative bioavailability falls within 0.80-1.25.

Q3: When is relative bioavailability used?
A: It's used in pharmaceutical development, generic drug approval processes, and when comparing different formulations of the same drug.

Q4: What factors affect bioavailability?
A: Formulation factors, absorption rate, first-pass metabolism, and physiological factors can all affect drug bioavailability.

Q5: How is AUC measured?
A: AUC (Area Under the Curve) is typically measured through pharmacokinetic studies where blood samples are taken at various time points after drug administration.