Home
Back
Formula Used:
| From: | To: |
The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time. It represents the efficiency of drug elimination from the body.
The calculator uses the formula:
Where:
Explanation: The formula calculates the volume of plasma that would be completely cleared of the drug per unit time based on the elimination rate constant and volume of distribution.
Details: Accurate calculation of plasma clearance is crucial for determining drug dosing regimens, understanding drug elimination kinetics, and assessing renal or hepatic function in drug metabolism.
Tips: Enter elimination rate constant in 1/s, volume of distribution in m³. All values must be valid positive numbers.
Q1: What is the elimination rate constant?
A: Elimination Rate Constant is the rate at which a drug is removed from the body, representing the fraction of drug eliminated per unit time.
Q2: What does volume of distribution represent?
A: Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body, indicating how widely a drug is distributed in body tissues.
Q3: What are typical units for these measurements?
A: Elimination rate constant is typically measured in 1/h or 1/s, volume of distribution in liters or m³, and plasma clearance in mL/min or m³/s.
Q4: How does plasma clearance relate to drug half-life?
A: Plasma clearance is inversely related to drug half-life. Higher clearance values generally indicate shorter half-lives and faster drug elimination.
Q5: What factors affect plasma clearance?
A: Plasma clearance is affected by renal function, hepatic function, blood flow to eliminating organs, protein binding, and the drug's physicochemical properties.